About CeeNU (Lomutisine)
CeeNU (lomustine) is a nitrosourea anti-tumor alkylating agent, and unlike the more common nitrogen mustard alkylating agents, lomustine readily crosses from the blood into the brain and is used in the treatment of brain tumors in people. Some other anti-tumor alkylating agents similar to lomustine include carmustine and streptozotocin.
This drug works by bonding with DNA of rapidly dividing cells to cause genetic defects, resulting in cell death. Since malignant cancer cells typically divide rapidly, these cells are most likely attacked by the drug. Other normal rapidly dividing body cells such as hair and gastrointestinal lining cells may also be affected, resulting in side effects.
Lomustine has been primarily used in dogs but recent studies have indicated that the drug may also be effective in cats. This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug.
Who's CeeNU (Lomutisine) For?
- Used in the treatment of lymphosarcoma and mast cell tumors
- May show promise in the treatment of brain tumors of dogs, which is the primary use in humans
Side Effects and Warnings
- CeeNU should not be used in animals with known hypersensitivity or allergy to the drug
- CeeNU should be used with extreme caution in animals with kidney disease and liver abnormalities since it can cause liver damage and kidney damage
- This drug may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with CeeNU
- The most significant effect of CeeNU is associated with the bone marrow and lymphoid tissue. Anemia, low white blood cell counts and low platelets can occur
- Other adverse effects of CeeNU include hair loss, severe vomiting, diarrhea and lack of appetite
- Consult your veterinarian regarding any allergies your pet may have, and any other side effects of this medication
CeeNU (Lomutisine) Directions
Use as directed by your veterinarian